Explain the induced fit model for mode of enzyme action.
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Induced-fit model A proposed mechanism of interaction between an enzyme and a substrate. It postulates that exposure of an enzyme to a substrate causes the active site of the enzyme to change shape in order to allow the enzyme and substrate to bind (see enzyme–substrate complex).
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The induced fit model of enzyme action was proposed by Koshland (1959) which states that substrates coming near the enzyme brings about a conformational change. It is an accepted model. This shows that enzymes are flexible structures in which active site reshapes interactions with substrate.
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