Question

explain the locking of conformation​

Answer 1

Answer:

Conformations that correspond to local maxima on the energy surface are the transition states between the local-minimum conformational isomers. Rotations about single bonds involve overcoming a rotational energy barrier to interconvert one conformer to another.

Answer 2

Answer:

For locking of conformation, we have to consider the following points.

• Confirmation means an infinite number of possible spatial arrangements of the atoms in a molecule.
• The isomers can be interconverted by the rotation of their constituent group about a single bond.
• Locking of conformation observed in Cyclohexane.
• Cyclohexane may acquire either axial or equatorial positions.
• In 1,3-diaxial, interaction becomes intense due to the presence of internal butane gauche interaction. So stability decreased.
• Therefore large substituents like t-butyl prefer equatorial positions to avoid di-axial interactions.
• And existence in only one conformation is termed as locking of conformation.

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