Question

explain the orientation of epoxide ring opening​

Answer 1

write an equation to describe the opening of an epoxide ring under mildly acidic conditions. ... base. explain why epoxides are susceptible to cleavage by bases, whereas other cyclic ethers are not.

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Answer 2

In the discussion on base‑catalyzed epoxide opening, the mechanism is essentially SN2. While oxygen is a poor leaving group, the ring strain of the epoxide really helps to drive this reaction to completion. Indeed, larger cyclic ethers would not be susceptible to either acid‑catalyzed or base‑catalyzed cleavage under the same conditions because the ring strain is not as great as in the three‑membered epoxide ring.