Explain the role of initiator trna in initiation of protein synthesis
Answers
A special initiator tRNA, tRNA met I (I stands for initiator) is used for beginning protein synthesis. In bacteria, this initiator tRNA carries the modified amino acid N‐formylmethionine (fmet). The formylation reaction transfers the formyl group from formyl‐tetrahydrofolate to methionyl‐tRNA metI +. This initiator tRNA is used to recognize initiation codons; it does not insert met in response to an internal AUG codon. As a further safeguard, the formylation reaction ensures that the initiator methionine can only be at the amino terminus of the synthesized protein
⏮Initiator tRNA carries amino acid methionine at its amino acid binding site and has anticodon UCA at its anticodon binding site.
⏮ Initiator tRNAbinds with the codon (AUG) present on the mRNA and in this way the initiator tRNA plays a role in initiation of protein synthesis.