Explain the role of NADPH in reductive biosynthesis
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NADPH ANABOLIC ENERGY
The cofactor NADPH provides high-energy electrons for antioxidant defense and reductive biosynthesis. Consumption and production of NADPH is compartmentalized, with cytosolic NADPH used by enzymes including fatty acid synthase, ribonucleotide reductase, thioredoxin reductase, and glutathione reductase
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NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species (ROS), allowing the regeneration of glutathione (GSH). ... The NADPH system is also responsible for generating free radicals in immune cells by NADPH oxidase.
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