explain the synthesis of furan
Answers
The Paal–Knorr Synthesis in organic chemistry is a reaction that generates either furans, pyrroles, or thiophenes from 1,4-diketones. It is a synthetically valuable method for obtaining substituted furans and pyrroles, common structural components of many natural products. It was initially reported independently by German chemists Carl Paal and Ludwig Knorr in 1884 as a method for the preparation of furans, and has been adapted for pyrroles and thiophenesAlthough the Paal–Knorr synthesis has seen widespread use, the mechanism wasn't fully understood until it was elucidated by V. Amarnath et al. in the 1990s.
The furan synthesis requires an acid catalyst:[5]
Paal–Knorr furan synthesis
In the pyrrole synthesis a primary amine participates:
Paal–Knorr Pyrrole Synthesis
and in that of thiophene for instance the compound phosphorus pentasulfide:
Paal-Knorr thiophene synthesis
Explanation:
The furan synthesis requires an acid catalyst:
Paal–Knorr furan synthesis
In the pyrrole synthesis a primary amine participates:
Paal–Knorr Pyrrole Synthesis
and in that of thiophene for instance the compound phosphorus pentasulfide:
Paal-Knorr thiophene synthesis