Explain Topliss manual method
Answers
A procedure is described in which an initial small group of compounds is selected, tested, and ordered according to potency. The potency order in the group is then compared to the tabulated potency order calculated for various parameter dependencies relating to hydrophobic, electronic, and steric effects.
(1) A manual method for applying the hansch approach to drug design
(2) utilisation of operational schemes food analogue synthesis in drug design
(3) correlation of antihypertensive activity with structure in a series of 2H -1,2,4- benzothiadiazine 1,1-dioxide using the substituent constant .
(4) substituent constant for the 2H -1,2,4 benzothiadiazine 1,1 dioxide system .
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