explain very briefly stages of mitosis
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Mitosis is the phase of the cell cycle where the nucleus of a cell is divided into two nuclei with an equal amount of genetic material in both the daughter nuclei. It succeeds the G2 phase and is succeeded by cytoplasmic division after the separation of the nucleus.
Answer:
Prophase
Mitosis begins with prophase, during which chromosomes recruit condensin and begin to undergo a condensation process that will continue until metaphase. In most species, cohesin is largely removed from the arms of the sister chromatids during prophase, allowing the individual sister chromatids to be resolved. Cohesin is retained, however, at the most constricted part of the chromosome, the centromere (Figure 9). During prophase, the spindle also begins to form as the two pairs of centrioles move to opposite poles and microtubules begin to polymerize from the duplicated centrosomes.
Prometaphase
Prometaphase begins with the abrupt fragmentation of the nuclear envelope into many small vesicles that will eventually be divided between the future daughter cells. The breakdown of the nuclear membrane is an essential step for spindle assembly. Because the centrosomes are located outside the nucleus in animal cells, the microtubules of the developing spindle do not have access to the chromosomes until the nuclear membrane breaks apart.
Prometaphase is an extremely dynamic part of the cell cycle. Microtubules rapidly assemble and disassemble as they grow out of the centrosomes, seeking out attachment sites at chromosome kinetochores, which are complex platelike structures that assemble during prometaphase on one face of each sister chromatid at its centromere. As prometaphase ensues, chromosomes are pulled and tugged in opposite directions by microtubules growing out from both poles of the spindle, until the pole-directed forces are finally balanced. Sister chromatids do not break apart during this tug-of-war because they are firmly attached to each other by the cohesin remaining at their centromeres. At the end of prometaphase, chromosomes have a bi-orientation, meaning that the kinetochores on sister chromatids are connected by microtubules to opposite poles of the spindle.
Metaphase
Next, chromosomes assume their most compacted state during metaphase, when the centromeres of all the cell's chromosomes line up at the equator of the spindle. Metaphase is particularly useful in cytogenetics, because chromosomes can be most easily visualized at this stage. Furthermore, cells can be experimentally arrested at metaphase with mitotic poisons such as colchicine. Video microscopy shows that chromosomes temporarily stop moving during metaphase. A complex checkpoint mechanism determines whether the spindle is properly assembled, and for the most part, only cells with correctly assembled spindles enter anaphase.
Anaphase
A schematic diagram shows cohesin molecules being degraded by the separase enzyme in-between two separating sister chromatids. The chromatids are shown as grey, vertically-aligned noodles arranged beside each other in parallel. At the center of each sister chromatid is a dark grey half-circle, representing part of the centromere where the two sister chromatids were once together.
View Full-Size ImageFigure 10
Figure Detail
A schematic diagram shows the position of cohesin molecules on a replicated in prophase and metaphase. The sister chromatids look like vertically-aligned grey noodles arranged beside each other in parallel. They are attached at their center by a darker grey circle, representing the centromere. A grey arrow shows that the sister chromatids shorten and become thicker during prophase. In prophase, cohesin molecules are attached along the length of the arms of the two sister chromatids, but fall away during chromosome condensation. In metaphase, cohesin is concentrated at the centromere region and the arms of the sister chromatids no longer have any cohesin molecules associated with them.
View Full-Size ImageFigure 9
The progression of cells from metaphase into anaphase is marked by the abrupt separation of sister chromatids. A major reason for chromatid separation is the precipitous degradation of the cohesin molecules joining the sister chromatids by the protease separase (Figure 10).
Two separate classes of movements occur during anaphase. During the first part of anaphase, the kinetochore microtubules shorten, and the chromosomes move toward the spindle poles. During the second part of anaphase, the spindle poles separate as the non-kinetochore microtubules move past each other. These latter movements are currently thought to be catalyzed by motor proteins that connect microtubules with opposite polarity and then "walk" toward the end of the microtubules.