Question

Explain what happens when a cellular process is not occurring

Answer 1

Explanation:

Cellular processes, such as transcription, DNA replication, and DNA repair, are regulated by an intimate and self-reinforcing crosstalk and interdependence between histone-modifying complexes and other histone-modifying activities, such as acetylation, phosphorylation, and methylation.

Consistent with the critical function of histone modifications in key cellular processes, a large body of evidence has suggested that aberrations in these modifications are intimately linked to human pathologies. Most notably, recent genetic and molecular studies have directly implicated histone modifications and histone-modifying complexes in human cancer [281,282]. The fact that epigenetic alterations are, in contrast to genetic changes, reversible has important implications for human cancer treatment, as aberrant histone modifications are potential molecular targets for therapeutic intervention in human malignancies.