Question

Explain why levodopa is usually combined with a dopa decarboxylase inhibitors in the treatment of parkinsonism

Answer 1

For this reason levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI), in this case carbidopa, which is very polar

Answer 2

Carbidopa/levodopa remains the most effective drug to treat PD. In addition to helping prevent nausea, carbidopa prevents levodopa from being converted into dopamine prematurely in the bloodstream, allowing more of it to get to the brain.

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