Explain why the absence of triose phosphate isomerase would be lethal to an organism fermenting glucose exclusively through tge glycolytic pathway
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Here's the answer ⤵
✔Triose Phosphate Isomerase is a glycolytic enzyme that converts Dehydroxy Acetone Phosphate (DHAP) to Glyceraldehyde-3-Phosphate (G3P), which will then enter the payoff phase of glycolysis.
✔Fructose-1,6-bisphosphate is also converted to G3P by the enzyme Aldolase.
✔The two molecules of G3P are thus what give the yield of 4 ATP molecules, 2 ATP per G3P. A defect in the Triose Phosphate Isomerase enzyme would mean that 2 ATP molecules would be lost and the payoff phase (which should then no more be called as such).
✔In the preparatory phase of Glycolysis, 2 ATP are invested and this would mean, overall there is no net ATP yield.
✔For organisms that use Glycolysis solely for metabolism, a defect in the enzyme thus means death since there is no ATP being produced.
Hope it helps ✌
Here's the answer ⤵
✔Triose Phosphate Isomerase is a glycolytic enzyme that converts Dehydroxy Acetone Phosphate (DHAP) to Glyceraldehyde-3-Phosphate (G3P), which will then enter the payoff phase of glycolysis.
✔Fructose-1,6-bisphosphate is also converted to G3P by the enzyme Aldolase.
✔The two molecules of G3P are thus what give the yield of 4 ATP molecules, 2 ATP per G3P. A defect in the Triose Phosphate Isomerase enzyme would mean that 2 ATP molecules would be lost and the payoff phase (which should then no more be called as such).
✔In the preparatory phase of Glycolysis, 2 ATP are invested and this would mean, overall there is no net ATP yield.
✔For organisms that use Glycolysis solely for metabolism, a defect in the enzyme thus means death since there is no ATP being produced.
Hope it helps ✌
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