Explain with suitable examples, damage of DNA by hydrolysis and deamination.
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Hydrolytic DNA damage involves deamination or the total removal of individual bases. Loss of DNA bases, known as AP (apurinic/apyrimidinic) sites, can be particularly mutagenic and if left unrepaired they can inhibit transcription. ... Pyrimidine dimers can disrupt polymerases and prevent proper replication of DNA.
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