Question

Expression of b7-1 and b7-2 in normal cell, dc and cancer cell

Answer 1

Induction of B7-1 and B7-2 costimulatory molecules. Owing to the frequent lack of B7-1 and B7-2, tumor cells are not able to deliver the costimulatory signals necessary for efficient effector T-cell activation. ... However, expression of B7-1 and B7-2 alone failed to induce immunity against poorly immunogenic tumors [81].