Question

facilitated diffusion of transcription factor proteins with anomalous bulk diffusion

Answer 1

What are the physical laws of the diffusive search of proteins for their specific binding sites on DNA in the presence of the macromolecular crowding in cells? We performed extensive computer simulations to elucidate the protein target search on DNA. The novel feature is the viscoelastic non-Brownian protein bulk diffusion recently observed experimentally. We examine the influence of the protein-DNA binding affinity and the anomalous diffusion exponent on the target search time. In all cases an optimal search time is found. The relative contribution of intermittent three-dimensional bulk diffusion and one-dimensional sliding of proteins along the DNA is quantified. 


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Answer 2

Á N S W E R :-

Facilitated diffusion is the passive movement of molecules across the cell membrane via the aid of a membrane protein

☞It is utilised by molecules that are unable to freely cross the phospholipid bilayer (e.g. large, polar molecules and ions).

☞This process is mediated by two distinct types of transport proteins – channel proteins and carrier proteins

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