Question

features of non persistent viral infection

Answer 1

Persistent virus infections are discussed from the virus
point of view in terms of the bodily sites in which the
infection persists. Glands and body surfaces are
thought to be significant because they give the virus
protection at the topographical level from immune
forces, and because they are appropriate sites for the
shedding of virus to the exterior. Germ cells are rele-
vant sites because infection can thus be transmitted
vertically from generation to generation in the host.
The central nervous system, however, is generally a
'dead end' from which there is no shedding to the
exterior. Persistence in blood may be relevant when
continued arthropod transmission becomes possible.
Most persistent viruses infect lymphoreticular tissues,
and this is interpreted by suggesting that it results in
an impaired immune response to the infecting virus,
which in turn favours persistence.
It is suggested that the biological function of virus
transformation and the integration of viral into host
cell DNA is that it enables the infection to persist in
the host and undergo reactivation. Papovaviruses,
adenoviruses and oncornaviruses are considered from
this point of view.

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