For packing of a negatively charged DNA, a positively charged histone molecules rich in basic amino acids are required. This histones are formed during :
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Nuclear DNA does not appear in free linear strands; it is highly condensed and wrapped around histones in order to fit inside of the nucleus and take part in the formation of chromosomes. Histones are basic proteins, and their positive charges allow them to associate with DNA, which is negatively charged.
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