For The Patient, Who Have Allergic Sensitivity, Would You Recommend Nsaid (non-steroidal Anti-inflammatory) Drugs Like Nimesulide?
Answers
After beta lactam antibiotics, hypersensitivity reactions to nonsteroidal anti-inflammatory drugs are the second cause of hypersensitivity to drugs. Acute manifestations affect the respiratory tract (aspirin exacerbated respiratory disease), the skin (urticaria and angioedema), or are generalized (anaphylaxis). Correct diagnosis and treatment in order to prevent unnecessary morbidity and the potential risk of death from these severe reactions, and to provide proper medical advice on future drug use frequently requires the participation of allergology specialists familiar with these clinical conditions.
The nomenclature for reactions to NSAIDs in the medical literature is somewhat confusing because authors have employed diverse terms in their reports, for example, pseudoallergy, idiosincrasia, or intolerance. We will use the terminology proposed by the Nomenclature Committee of the World Allergy Organization that defines drug hypersensitivity as the symptoms or signs initiated by exposure to a drug at a dose normally tolerated by non-hypersensitive persons. “Drug allergy” refers to immunologically mediated drug hypersensitivity reactions. These may be either immunoglobulin E (IgE)-mediated (immediate) or non IgE-mediated (delayed). “Non allergic hypersensitivity reactions” refer to adverse drug reactions that are not mediated by immunological mechanisms [4].