From the following,which molecular has most sheilded protons?
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molecule F actually has the most shielded AND deshielded protons.
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CH3
As a result, the proton in CH3 are shielded the most (up the field), the protons in CH2 are midway, and the H linked straight to O is shielded the least (downfield).
The proton of the amides in a protein's backbone are indeed a type of exchangeable protons that are routinely investigated in this way. The approach reveals the tertiary structure of a protein by revealing the solvent permeability of distinct sections of the molecule.
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