Question

Function of sampling ports in bioreacters

Answer 1

Answer:

The necessity of maintaining and knowing the current growth status and reactor broth conditions are several of the more critical bioprocess operations in fermentation and cell culture. In order to control and optimize bioreactor functions, frequent aseptic sampling of these operations is required. Many environmental and process factors may influence/interfere with proper bio-sampling. The primary goal is to maintain asepsis during the sampling process and that the sample’s integrity must not be compromised. This article will focus on key bio sampling requirements with special emphasis on automated sampling systems. Components, materials, industry specifications and regulatory requirements will be covered.