Gabriel phthalimide synthesis is used in the preparation of
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1° amine s are produced by this method.
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✔Aromatic amines cannot be prepared by Gabriel Phthalimide synthesis reaction because aryl halides do not undergo nucleophilic substitution with the anion formed by phthalimide.
✔It is used for the preparation of primary aliphatic amines.
✔Phthalimide on treatment with ethanolic potassium hydroxide forms potassium salt of phthalimide which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding primary amine.
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