Genome can get duplicated in successive generations. How can this problem be solved?
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The amount of gene product produced is often critical for proper cellular function, but with all genes copied, the complex regulatory network may be modified in peculiar ways. To solve this problem, cells turn off or at least turn down the expression of some copies of some genes.
After a whole genome duplication, there is a relatively short period of genome instability, extensive gene loss, elevated levels of nucleotide substitution and regulatory network rewiring. In addition, gene dosage effects play a significant role.
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