Give a schematic representation of the transformation of a pro-insulin
into insulin.
Answers
Answer:
pro-insulin is made up of 3 polypeptide chains A, B and C . while insulin have only polypeptide A and B. polypeptide C chain make the insulin into pro insulin...
Explanation:
Proinsulin is a particular polypeptide series made of the B and A subunits of insulin followed by the C-peptide region. Proinsulin is transformed into insulin throughout the maturation of secretory swellings by the work of two proteases and metabolism is hindered by ionophores that disturbed intracellular H+ pitches. To decide if the turn of prohormone to hormone really happens in an acidic secretory swelling, cultured rat islet cells were produced in the closeness of 3-(2,4-dinitroanilino)-3' amino-N-methyldipropylamine (DAMP), a central congener of dinitrophenol that accumulates in acidic cells and is maintained following aldehyde obsession. The cells obtained prepared for indirect proteid A-gold colocalization of DAMP, using a monoclonal immunoglobulin to dinitrophenol, and proinsulin, using a monoclonal immunoglobulin that completely takes with the prohormone. The medium consistency of DAMP-specific metal bits in juvenile secretory swellings that included proinsulin was 71/micron 2, which meant that this section was acidic. Though, the quantity of DAMP-specific metal scraps in the insulin-rich developed secretory swelling averaged 433/micron 2. This implies that although proinsulin conversion happens in an acidic part, the secretory swellings grow more acidic as they grow.
To learn more:
i)Difference between proinsulin and insulin - Brainly.in
https://brainly.in/question/1453637
ii)Why is proinsulin so called? How is insulin different from it? - Brainly.in
https://brainly.in/question/7597965