Question

Given below is the representation of a relevant part of amino acid composition of the β-chain of haemoglobin, related to the shape of human red blood cells.
(a) Is this representation of the sequence of amino acids indicating a normal human or a sufferer from a certain blood related genetic
disease? Give reason in support of your answer.
(b) Why is the disease referred to as a Mendelian disorder? Explain.

Answer 1

This chain shows normal genetic setup.

This is a mendelian disorder because this can be transferred from parents to offsprings just like experiments done by Mendel.

Explanation:

• The haemoglobin of human contains 4 chains - 2 alpha chains and 2 beta chains.

• The beta chains shown in this diagram is the condition of normal beta chain.

• Had the 6th amino acid of the beta chain, which is glutamic acid, is replaced by valine, then there would have been a disease.

• The disease is called sickle celled anemia.

• This is a mendelian disorder because the characters of the disease is carried forward to next generations just like other characters.

For more information about Sickle cell anemia,

https://brainly.in/question/14726722

What combination of genes of sickle cell anemia is lethal?

https://brainly.in/question/2927247

A couple both carrier of sickle cell anemia planning to get married want to know the chance of having anemic progeny.?

Answer 2

Answer:

In humans, Mendelian disorder is a type of genetic disorder primarily resulting due to alterations in one gene or as a result of abnormalities in the genome. Such a condition can be seen since birth and be deduced on the basis of family history using the family tree.