Question

Glucokinase acts as a glucose sensor in hepatocytes (liver cells), α- and β-cells in the pancreas, enterocytes (intestinal wall cells), and the hypothalamus (a control center in the brain of numerous physiological processes). Explain why glucokinase can perform this role ???
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Answer 1

Answer:

Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

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