Question

Graft rejection is mediated by
(A) B - cells
(B) T-cells
(C) Plasma cells
(D) NK cells​

Answer 1

ANSWER:

T cells is the answer

EXPLANATIONS:

WHAT IS IMMUNITY:

• Immunity is the body's defense mechanism against foreign particles that are entering in our body.

• There are two types of immunity in our body.

• They are humoral or antibody mediated immunity and cell mediated immunity.

• Humoral immunity is due to B lymphocytes or B cells.

WHAT IS GRAFT REJECTION:

• Grafts refer to the organs that are taken from one organism to and get transplanted in other organism.

• When the graft is transplanted into the recipient, the recipient body does not accept the graft immediately.

• The rejection of graft occurs due to our body immune system.

• The main reason for graft rejection is cell mediated immunity.

• Cell mediated immunity is caused by T cells or T lymphocytes.

WAYS TO AVOID GRAFT REJECTION:

• It is necessary to match the Major Histocompatibility Factor of both graft and the recipient body.

• Blood group must be matched.

• To avoid the adverse effect of immunity towards graft, immunosuppressants like cyclosporin are given to the recipient before graft transplant.

Answer 2

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Graft rejection is mediated by

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B) T - Cells

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$\small\orange{\sf { Explanation :—}}$

• Transplantation is the most effective treatment for end-stage organ failure, but organ survival is limited by immune rejection and the side effects of immunosuppressive regimens.

• T cells are central to the process of transplant rejection through allorecognition of foreign antigens leading to their activation, and the orchestration of an effector response that results in organ damage.

• Long-term transplant acceptance in the absence of immunosuppressive therapy remains the ultimate goal in the field of transplantation and many studies are exploring potential therapies. One promising cellular therapy is the use of regulatory T cells to induce a state of donor-specific tolerance to the transplant.

• This article first discusses the role of T cells in transplant rejection, with a focus on the mechanisms of allorecognition and the alloresponse. This is followed by a detailed review of the current progress in the field of regulatory T-cell therapy in transplantation and the translation of this therapy to the clinical setting.

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