Question

H2o2 is catalyzed (reduction) by platinum nanoparticles to generate water on hydrogen peroxide

Answer 1

Au@ Pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays

Weiwei He, Ying Liu, Jinshan Yuan, Jun-Jie Yin, Xiaochun Wu, Xiaona Hu, Ke Zhang, Jianbo Liu, Chunying Chen, Yinglu Ji, Yuting Guo

Biomaterials 32 (4), 1139-1147, 2011

In this paper, we demonstrated that Au nanorods coated with a shell composed of Pt nanodots (Au@Pt nanostructures) exhibited intrinsic oxidase-like, peroxidase-like and catalase-like activity, catalyzing oxygen and hydrogen peroxide reduction and the dismutation decomposition of hydrogen peroxide to produce oxygen. Based on these findings, we established an Au@Pt nanostructures based enzyme linked immunosorbent assay (ELISA) for the detection of mouse interleukin 2 (IL-2). In comparison with natural enzymes, Au@Pt nanostructures …

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Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide

Masashi Kajita, Keisuke Hikosaka, Mayumi Iitsuka, Atsuhiro Kanayama, Naoki Toshima, Yusei Miyamoto

Free radical research 41 (6), 615-626, 2007

Bimetallic nanoparticles consisting of gold and platinum were prepared by a citrate reduction method and complementarily stabilized with pectin (CP-Au/Pt). The percent mole ratio of platinum was varied from 0 to 100%. The CP-Au/Pt were alloy-structured. They were well dispersed in water. The average diameter of platinum nanoparticles (CP-Pt) was 4.7±1.5 nm. Hydrogen peroxide (H2O2) was quenched by CP-Au/Pt consisting of more than 50% platinum whereas superoxide anion radical () was quenched by any CP-Au/Pt. The CP-Au/Pt quenched these two reactive oxygen species in dose-dependent manners. The CP-Pt is the strongest quencher. The CP-Pt decomposed H2O2 and consequently generated O2 like catalase. The CP-Pt actually quenched which was verified by a superoxide dismutase (SOD) assay kit. This quenching activity against persisted like SOD. Taken together, CP-Pt may be a SOD/catalase mimetic which is useful for medical treatment of oxidative stress diseases.