Question

He is blind ____ one eye.(Fill in the blank with correct preposition)

Answer 1

He is blind in one eye.

You will find blind of one eye in older or archaizing literature though, for example here:
But the hunters found out that she was blind of one eye, and hiring a boat rowed under the cliff where she used to feed and shot her from the sea.
The One-Eyed Doe - Fables of Aesop

However, the correct preposition to be used here is 'in'.

The following examples will verify the usage:

Holmes says Victor is blind in one eye; he couldn't have hit a moving target (the third person from the last murder).


Wilson had suffered a stroke which left him blind in one eye, paralyzed on one side and somewhat restricted mentally.


He was left paralyzed down his left side, unable to speak properly, blind in one eye and barely able to eat or dress.

Answer 2

He is blind in one eye.

In the above situation, the correct preposition is in.

In is an example of a simple preposition and is used to show the relationship between two things.

Here, the preposition in indicates the relationship between the words ‘blind’ and’eye’.