Hello guys....
Explain how Gene therapy is better option than bone marrow transplant for SCID syndrome!?
Also suggest best cure for it!?
Answers
Answer:
Gene therapy is modern technique which is much more reliable and effective incase of SCID whereas bone marrow is not that effective as well it may result in graft rejection by humoral immunity which can be fatal for the patient.
As SCID is an autoimmune disorder so there is no proper cure for it except for gene therapy and few other treatments.
Answer:
Gene therapy is a form of molecular medicine based on the addition of a corrected copy of a gene to the somatic cells of an individual in order to cure or to alleviate his/her disease. This strategy may provide new treatments for a large number of inherited diseases in the near future.
The practical use of gene therapy is currently limited to 2 cell types: accessible stem cells and terminally differentiated, postmitotic, long-lived cells. The characteristics of the target cells greatly influence the choice of viral vector for gene delivery; vectors able to integrate into the host genome are necessary when dividing cells are targeted, in order to ensure the replication of the transgene, while nonintegrative vectors can be used when gene transfer is performed in postmitotic cells. RNA viruses (retro- and lentiviruses) are used to mediate integrative gene transfer (1, 2). Conversely, DNA viruses provide nonintegrative means of transferring therapeutic genes. Two viruses have been abundantly used in clinical trials of gene therapy (3–5): adenovirus (Ad) and adeno-associated virus (AAV).