hexokinase belongs to which class of enzymes
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A hexokinase is an enzyme that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. In most tissues and organisms, glucose is the most important substrate of hexokinases, and glucose 6-phosphate the most important product.
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Hexokinase belongs to the transferase class of enzymes.
- Transferase class of enzymes catalyzes the transfer of specific groups such as amino groups, phosphate groups or acetyl groups from the donor molecule to the acceptor molecule.
- The reaction is as-
A group + B ------> A + B group, where A is the donor and B is the acceptor.
- Transferases are further classified into groups or subclasses depending on the type of biochemical group that they transfer.
- Hexokinase is a phosphotransferase as it catalyzes the phosphorylation of glucose,i.e. transfers a phosphate molecule from Adenosine Triphosphate( ATP) to glucose to give Glucose-6-phosphate.
- The reaction is-
Glucose + ATP -------> Glucose-6-Phosphate + ADP
It is the first reaction in glycolysis.
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