Question

higher doses of drugs need to be taken with repeated use​

Answer 1

Answer:

In repeated administration, accumulation occurs when the drug is administered before the previous dose is completely eliminated. The amount of drug in the body will then progressively rise. ... Therefore, the plasma concentration fluctuates between doses similarly from one dosing interval to another.

Answer 2

Answer:

In repeated administration, accumulation occurs when the drug is administered before the previous dose is completely eliminated. The amount of drug in the body will then progressively rise.  Therefore, the plasma concentration fluctuates between doses similarly from one dosing interval to another.

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