Question

His entire career was beset...... difficulties.

Answer 1

The answer can wholly change if we use different words.

If we use His entire career was best with difficulties it means he had difficulties in his entire career.

Again if we write His entire career was beset by difficulties it means there were no difficulties.

Answer 2

His entire was beset with difficulties .

This was a question requiring us to fill the blanks with the appropriate word.

" With " is the appropriate word used here.

The sentence has complete meaning .

The sentence tells us " The career of the person was full of difficulties ".

We need to understand that the sentence is meaningful and then only the word inserted will be correct.