Histone methyltransferase gene setd2 is a novel tumour suppressor gene in clear cell renal cell carcinoma
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Histone methyltransferase. ... In eukaryotic cells, the genome is tightly condensed into chromatin (composed of DNA and histoneproteins), so enzymes, such as histone methyltransferases, must overcome this inaccessibility. Histone methyltransferase does so by modifying histones at certain sites through methylation.
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Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Like other types of cancer, carcinomas are abnormal cells that divide without control. They are able to spread to other parts of the body, but don't always.
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