Question

History of tetracycline antibiotics in acne vulgaris

Answer 1

The most sensitive biochemical reaction that is inhibited is the synthesis of proteins [21]. Tetracycline works by binding specifically to the 30S ribosome of the bacteria, preventing attachment of the aminoacyl tRNA to the RNA-ribosome complex. It simultaneously inhibits other steps of the protein biosynthesis.
Tetracycline works by slowing down the growth of the bacteria that cause acne. It also acts as an anti-inflammatory, so it helps make pimples less swollen and red. Tetracycline is used to treat moderate to severe acne, although it's sometimes prescribed for mild inflammatory acne that is particularly stubborn.