how a-hydroxy acids are produced from aldehydes and ketones?
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CH
3
−CHO
(i)NaCN/HCl
(ii)H
2
O/H
⊕
/Δ
Treatment of acetaldehyde with sodium cyanide in presence of HCl gives acetaldhyde cyanohydrin.
This is followed by hydrolysis of cyano group in presence of acid to form hydroxy acid as a product which is 2-hydroxy propanoic acid.
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Various terminal olefinic compounds are directly converted into the corresponding α-hydroxy ketones in good yields by potassium permanganate oxidation. The reaction is highly chemoselective in the presence of differently protected hydroxy groups.
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