Chemistry, asked by sushant8812, 1 month ago

How alkylation of base can cause DNA damage?

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Answered by snehasunil026

Answer:

The alkylating agents transfer alkyl (chemical) groups to DNA. DNA alkylation in the nucleus leads to the death of the cell. Once in the cell, the alkylating agents undergo a structural rearrangement that results in the formation of an unstable intermediate, an ethylene immonium ion

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