how are the blood vessels leakages plugged in the body?
Answers
Explanation:
Leaky vessels alone can lead to major health problems, and this new pathway may provide insights into how it occurs. In addition, some newer cancer therapeutics target the Notch pathway in an effort to block the overgrowth of cells. By blocking the entire Notch pathway, these drugs may also be inhibiting the heretofore unknown function of sealing blood vessel walls, causing them to leak. Indeed, these drugs have reported such side effects, and until now, clinicians have been at a loss to explain why this occurs. Polacheck and Kutys may have found the answer.
“Going forward, we hope to establish a better understanding of where and when this pathway contributes to health and disease,” says Chen. “We also will continue our efforts to build new cell culture platforms that can be used to mimic and study important disease processes.”
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