Question

How are viruses referred to in which their envelope proteins have been replaced by other proteins, like vsv-g, to increase the tropism?

Answer 1

Viral vectors have natural host cell populations that they infect most efficiently. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are refractory to infection by these viruses as well. Attachment to and entry into a susceptible cell is mediated by the protein envelope on the surface of a virus.......

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