How can one, all by himself, fight Clinical Depression due to Hashimoto's Thyroiditis as well as solitude and despondency; While also ensuring that he can study 10hrs/day productively without suffering a Mental Breakdown.(Socialising ain't cutting it.)
Answers
Answer:
How can one, all by himself, fight Clinical Depression due to Hashimoto's Thyroiditis as well as solitude and despondency; While also ensuring that he can study 10hrs/day productively without suffering a Mental Breakdown.(Socialising ain't cutting it.)
Explanation:
Depression due to Hashimoto's Thyroiditis as well as solitude and despondency.
The importance of thyroid hormones on cerebral development and functioning are highlighted by the devastating neurological consequences of severe iodine deficiency [1,2], MCT8 mutations [3,4] and untreated congenital hypothyroidism [5,6]. Furthermore, we have come to realise the importance of thyroid hormone transporters and iodothyronine deiodinases in delivering the hormones to where they have their actions [7].
In animal studies, thyroid hormones influence noradrenergic and serotonergic neurotransmission which play a key role in the pathogenesis of depression and are targets for current antidepressant therapies [8,9,10,11,12,13]. These studies have shown increased serotonin levels in the cerebral cortex of rats after T3 administration and also decreased serotonin synthesis in the brain with hypothyroidism. Serotonin also has an inhibitory effect on thyrotropin-releasing hormone (TRH) secretion suggesting a feedback loop which allows activation of the hypothalamus-pituitary-thyroid axis when serotonin levels in the brain are low.