How can you use the method of Gabriel phthalimide synthesis to synthesize alanine? Give the reactions with the mechanism.
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Gabriel Phthalimide Synthesis Mechanism has 3 steps. The Synthesis is used to get primary amines from primary alkyl halides and is named after the German scientist Siegmund Gabriel.
The reaction has been generalized for applications in the alkylation of sulfonamides and imides & their deprotection in order to obtain amines. Alkylation of ammonia is quite inefficient, therefore it is substituted with ophthalmoscope anion in the Gabriel synthesis.
Synthesis Details
The biggest advantage of using the Gabriel synthesis is the avoidance of over alkylation. A good nucleophile in the form of an imide ion is also formed with the reaction of potassium hydroxide with the phthalimide.
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