How could Induced pluripotent stem cells be used for long-term treatment of sickle cell disease in humans? Make sure to use the words stem cell, mitosis, and differentiation correctly in your answer
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Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused on methods of iPSC production without the genetic modification of the cell genome and with means for increasing the iPSC production efficiency. The possibility and issues related to the safety of iPSC use in cell replacement therapy of human diseases and a study of new medicines are considered.
Keywords: induced pluripotent stem cells, directed stem cell differentiation, cell replacement therapy.
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