Question

How did Griffith prove transforming principle in Genetics. Explain the procedure.

Answer 1

Answer:

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Explanation:

in 1928 by Frederick Griffith,[1] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.[2][3] Griffith's findings were followed by research in the late 1930s and early 40s that isolated DNA as the material that communicated this genetic information.

in 1928 by Frederick Griffith,[1] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.[2][3] Griffith's findings were followed by research in the late 1930s and early 40s that isolated DNA as the material that communicated this genetic information.Pneumonia was a serious cause of death in the wake of the post-WWI Spanish influenza pandemic, and Griffith was studying the possibility of creating a vaccine. Griffith used two strains of pneumococcus (Streptococcus pneumoniae) bacteria which infect mice – a type III-S (smooth) which was virulent, and a type II-R (rough) strain which was nonvirulent. The III-S strain synthesized a polysaccharide capsule that protected itself from the host's immune system, resulting in the death of the host, while the II-R strain did not have that protective capsule and was defeated by the host's immune system. A German bacteriologist, Fred Neufeld, had discovered the three pneumococcal types (Types I, II, and III) and discovered the quellung reaction to identify them in vitro.[4] Until Griffith's experiment, bacteriologists believed that the types were fixed and unchangeable, from one generation to another.