Question

How did the teachey explain binds jlight?​

Answer 1

Myosin V is a double-headed molecular motor involved in organelle transport. Two distinctive features of this motor, processivity and the ability to take extended linear steps of ≈36 nm along the actin helical track, depend on its unusually long light chain-binding domain (LCBD). The LCBD of myosin V consists of six tandem IQ motifs, which constitute the binding sites for calmodulin (CaM) and CaM-like light chains. Here, we report the 2-Å resolution crystal structure of myosin light chain 1 (Mlc1p) bound to the IQ2–IQ3 fragment of Myo2p, a myosin V from Saccharomyces cerevisiae. This structure, combined with FRET distance measurements between probes in various CaM–IQ complexes, comparative sequence analysis, and the previously determined structures of Mlc1p-IQ2 and Mlc1p-IQ4, allowed building a model of the LCBD of myosin V. The IQs of myosin V are distributed into three pairs. There appear to be specific cooperative interactions between light chains within each IQ pair, but little or no interaction between pairs, providing flexibility at their junctions. The second and third IQ pairs each present a light chain, whether CaM or a CaM-related molecule, bound in a noncanonical extended conformation in which the N-lobe does not interact with the IQ motif. The resulting free N-lobes may engage in protein–protein interactions. The extended conformation is characteristic of the single IQ of myosin VI and is common throughout the myosin superfamily. The model points to a prominent role of the LCBD in the function, regulation, and molecular interactions of myosin V.

Answer 2

It is absolutely true mother is the first teacher in every individual’s life. As a baby grows in his/her mother’s lap, the mother teaches him/her many things. She assists him/her in eating, drinking, balancing, etc.

I the story His First Flight by Liam O’ Flaherty, the mother’s role in teaching the growing babies has been highlighted. The young seagull had fear of jumping from the high sea ledge to fly; his brother and sister had already made their first flight. Everyone was waiting for him to jump and fly and join them on the plateau. He kept sitting on the ledge feeling hungry.

The mother seagull conceived of a plan; she broke a piece of meat from a fish and flew up to the ledge. But she did not go very lose to him. She kept hovering a little away from the ledge. The young seagull in an attempt to take food from his mother, fell from the ledge; this fall compelled him to open his wings. And soon he was flying.  

In conclusion we can say mothers really are the first and the best teachers.