how did xenon help in the treatment of heart and brain injuries
Answers
Answer:
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Explanation:
For brain injuries:
Xenon, a chemically inert but biologically active monatomic gas, has been applied in patients for anaesthesia/sedation, and most recently in the critical care of patients with acute ongoing neurological damage.
Following preclinical evidence that xenon has ameliorative activity in several pathobiologic pathways that are involved in central nervous system injury, xenon was shown to be effective at improving both morphology and function in a series of models of hypoxic/ischaemic injury that simulate stroke (both haemorrhagic and ischaemic), neonatal asphyxia, as well as the ischaemic-reperfusion injury that occurs in the post-cardiac arrest syndrome (PCAS).
These promising findings prompted a Phase 2 RCT that revealed that a 24-hour xenon administration during targeted temperature management (TTM) resulted in significantly less brain damage than TTM alone in PCAS. A pivotal, multicentre, Phase 3 RCT is now underway to establish the efficacy (primary endpoint is survival with good functional outcome) and safety of xenon in PCAS.
For heart injuries:
Xenon gas treatment progresses into drug development. An earlier study discovered that xenon protects the white matter in the brain from damage, and the latest research showed that xenon can also protect the heart. The studies showed that xenon protects the brain when patients are treated for cardiac arrest.
hope it will help you...