How do g-proteins aid in cell signalling?
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Cells have proteins called receptors that bind to signaling molecules and initiate a physiological response. ... Receptors are generally transmembrane proteins, which bindto signaling molecules outside thecell and subsequently transmit thesignal through a sequence of molecular switches to internalsignaling pathways.
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G proteins located within the cell are activated by G protein-coupled receptors (GPCRs) that span the cell membrane. Signaling molecules bind to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn activates a particular G protein.
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