How do quinolones/ floroquinolones work?
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Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating. ... Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription.
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Quinolones are a group of synthetic chemotherapeutic agents, which mean that ... Fluoroquinolones ... to the quinolone-binding pocket of DNA topoisomerases while they are working ...
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