Question

How does a phosphorylation cascade work? What does it do to the original signal?

Answer 1

A phosphorylation cascade is a sequence of events where one enzyme phosphorylates another, causing a chain reaction leading to the phosphorylation of thousands of proteins. This can be seen insignal transduction of hormone messages.

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Answer 2

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Phosphorylation of proteins can alter the activity of that protein, either inhibitory or stimulatory. Ìn signaling cascades it is most often stimulatory. Kinases are enzymes responsible for this phosphorylation.

Phosphorylation reactions often occur in series, or cascades, in which one kinase activates the next. These cascades serve to amplify the original signal, but also improving the signal (less noise) and allowing for cross talk between different pathways.

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