Question

How does an increase in the carbon dioxide concentration in the blood affect the pH of the cerebrospinal fluid?

Answer 1

Answer:

Over the short term, and without change in CSF bicarbonate, a rise in CSF Pco2 causes a fall in CSF pH. ... In both cases, carbon dioxide crosses the barrier and hydrates to carbonic acid, which then ionises to give a pH inversely proportional to the log of the Pco2. A hydrogen ion sensor is thus made to respond to Pco2.

Explanation:

An elevation of arterial Pco2 causes an approximately equal rise of extracellular fluid, CSF, cerebral tissue and jugular venous Pco2, which are all approximately 1.3 kPa (10 mmHg) more than the arterial Pco2. Over the short term, and without change in CSF bicarbonate, a rise in CSF Pco2 causes a fall in CSF pH.

Answer 2

Answer:

A hydrogen ion (H+) and a hydrogen carbonate ion can be created when carbon dioxide reacts with water to create carbonic acid (H2CO3), which then affects the pH of the blood (HCO3-). Thus, a lower pH and more H+ ions are produced when the blood's carbon dioxide concentration rises.

Explanation:

• Blood's pH can alter as a result of variations in the concentrations of carbon dioxide molecules and hydrogen ions, which can have a detrimental effect on brain function.
• Mammals use specialized cells in the brainstem known as central chemoreceptors, which can sense changes in the pH of the blood, to prevent this.
• The body reacts by controlling respiration and blood flow when these chemoreceptors notice such a shift.
• It is more challenging to notice pH variations in the brain when blood flow through the brain is changing, though.

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