How does glucose 6 phosphate inhibits hexokinase?
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Hexokinase, the enzyme catalyzing the first step of glycolysis, is inhibited by its product, glucose 6-phosphate. ... However, the liver, in keeping with its role as monitor of blood-glucose levels, possesses a specialized isozyme of hexokinase called glucokinase that is not inhibited by glucose 6-phosphate.
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Hexokinase, the enzyme catalyzing the first step of glycolysis, is inhibited by its product, glucose 6-phosphate. ... In turn, the level of glucose 6-phosphate rises because it is in equilibrium with fructose 6-phosphate. Hence, the inhibition of phosphofructokinase leads to the inhibition of hexokinase.
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