How does kidney make concentrated urine?
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In the presence of ADH, the medullary collecting ducts become freely permeable to solute and water. As a consequence, the fluid entering the ducts (en route to the renal pelvis and subsequent elimination) acquires the concentration of the interstitial fluid of the medulla; i.e., the urine becomes concentrated.
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It is now generally agreed that the formation of concentrated urine in the mammalian kidney is effected by the production of a highly concentrated environment around the medullary collecting ducts in which the final concentrating process occurs by osmotic equilibration of the collecting duct contents
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