How does the low ph of lysosomes protect the rest.Of the cell from lysosomal enzymes in case the lysosome breaks?
Answers
membrane and second, even if the enzymes were to leak out of the lysosome, they would not be active at the neutral pH of the cytosol. ... Intracellular materials, such as old organelles, are brought into a lysosome by a process called autophagy.
Answer: The correct answer is lysosomal enzymes are are active at the acidic or low pH ( pH 5 ) but gets inactivated at the neutral pH of 7.2 , of the cytoplasm.
Explanation: Lysosomes are membrane bound cell organelle which contain an array of enzymes mostly acidic in nature capable of breaking down all types of biological polymers and also degrade materials taken up from outside the cell and involved in the digestion of old or unwanted organelles or other cell structure in a process known as Autophagy.
All of the lysosomal enzymes are acid hydrolases which are active at the acidic pH 5 that is maintained within lysosome but not at the neutral pH of 7.2 , characteristic of rest of the cytoplasm. The requirement of these lysosomal hydrolases for acidic pH provides double protection against uncontrolled digestion of the contents of the cytosol and even if the lysosomal membrane were to break down, the released hydrolases would be inactive at the neutral pH of the Cytosol. To maintain their internal pH:
Lysosomes must actively concentrate H+ ions (protons) which is accomplished by a proton pump in the lysosomal membrane.
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